Severe food allergy and anaphylaxis : treatment, risk assessment and risk reduction

摘要

An anaphylactic reaction may be fatal if not recognised and managed appropriately with rapid treatment. Key steps in the management ofanaphylaxis include eliminating additional exposure to the allergen, basic life-support measures and prompt intramuscular administrationof adrenaline 0.01 mg/kg (maximum 0.5 mL). Adjunctive measures include nebulised bronchodilators for lower-airway obstruction,nebulised adrenaline for stridor, antihistamines and corticosteroids. Patients with an anaphylactic reaction should be admitted to a medicalfacility so that possible biphasic reactions may be observed and risk-reduction strategies initiated or reviewed after recovery from the acuteepisode.Factors associated with increased risk of severe reactions include co-existing asthma (and poor asthma control), previous severereactions, delayed administration of adrenaline, adolescents and young adults, reaction to trace amounts of foods, use of non-selectiveβ-blockers and patients who live far from medical care.Risk-reduction measures include providing education with regard to food allergy and a written emergency treatment plan on allergenavoidance, early symptom recognition and appropriate emergency treatment. Risk assessment allows stratification with provision ofinjectable adrenaline (preferably via an auto-injector) if necessary. Patients with ambulatory adrenaline should be provided with writteninstructions regarding the indications for and method of administration of this drug and trained in its administration. Patients and theircaregivers should be instructed about how to avoid foods to which the former are allergic and provided with alternatives. Permission mustbe given to inform all relevant caregivers of the diagnosis of food allergy. The patient must always wear a MedicAlert necklace or braceletand be encouraged to join an appropriate patient support organisation.